LasB-IN-1

LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 μM) . LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-κB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Elastase; NF-κB; p38 MAPK

Type

Reference compound

Related Pathways

Anti-infection; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lasb-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C(O)(CCCC)C3=C1C=CCC3

Molecular Formula

C20H22F3NO2

Molecular Weight

365.39

References & Citations

[1]Ping-Hua Sun, et al. Novel ligustilide derivatives target quorum sensing system LasR/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection. European Journal of Medicinal Chemistry. 2023, 263, 115972.