LasB-IN-1
LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 μM) . LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-κB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Elastase; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
Anti-infection; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lasb-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C(O)(CCCC)C3=C1C=CCC3
Molecular Formula
C20H22F3NO2
Molecular Weight
365.39
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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