R079

R079 (compound 17) is a selective, orally active Nrf2 activator. R079 increases Nrf2 translocation activity (EC50 = 32.41 μM) . R079 can neutralize excess levels of reactive oxygen species through activating Nrf2. R079 has anti-inflammatory properties and can be used in multiple sclerosis research [1].

Product Specifications

CAS Number

[2115659-62-4]

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r079.html

Solubility

10 mM in DMSO

Smiles

O=S(/C=C/N1C(N(C=N1)C)=O)(C2=CC=CC=C2)=O

Molecular Formula

C11H11N3O3S

Molecular Weight

265.29

References & Citations

[1] Simon J. Shaw, et al. Tuning the Reactivity of Nuclear Factor Erythroid 2 Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy. ACS Medicinal Chemistry Letters . 2023, Article ASAP.