EN884
EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs) [1].
Product Specifications
CAS Number
[2189497-60-5]
UNSPSC
12352005
Hazard Statement
H301-H311-H331-H341
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/en884.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC1)CC2=CC=CN=C2)C=C
Molecular Formula
C14H18N2O
Molecular Weight
230.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Seong Ho Hong, et al. Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation. bioRxiv. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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