EN884

EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs) [1].

Product Specifications

CAS Number

[2189497-60-5]

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/en884.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC(CC1)CC2=CC=CN=C2)C=C

Molecular Formula

C14H18N2O

Molecular Weight

230.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Seong Ho Hong, et al. Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation. bioRxiv. 2023.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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