α-Glucosidase-IN-43
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin -induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients[1].
Product Specifications
CAS Number
3018963-27-1
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/α-glucosidase-in-43.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(OCCCCCN2N=NC(COC3=CC(C(C)C)=CC=C3C)=C2)C4=C(O1)C=CC=C4
Molecular Formula
C27H31N3O4
Molecular Weight
461.55
References & Citations
[1]Singh A et al. Discovery of triazole tethered thymol/carvacrol-coumarin hybrids as new class of α-glucosidase inhibitors with potent in vivo antihyperglycemic activities. Eur J Med Chem. 2023 Nov 15;263:115948.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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