Microcolin H

Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy) . Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].

Product Specifications

CAS Number

[2408008-21-7]

UNSPSC

12352209

Target

Atg8/LC3; Autophagy; p62

Type

Natural Products

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/microcolin-h.html

Purity

99.13

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O

Molecular Formula

C38H63N5O9

Molecular Weight

733.93

References & Citations

[1]Yang H et al. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduct Target Ther. 2023 Nov 15;8 (1) :428.