MBL-IN-2

MBL-IN-2 ((2R, 2R') -5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC50 of 0.3 μM. MBL-IN-2 ((2R, 2R') -5αC) can be used for the study of resistance to β-lactam antibiotics[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mbl-in-2.html

Solubility

10 mM in DMSO

Smiles

SC[C@@H](C(F)(F)F)C(N1CCC[C@@H]1C(O)=O)=O

Molecular Formula

C9H12F3NO3S

Molecular Weight

271.26

References & Citations

[1]Kondratieva A, et al. Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose[J]. European Journal of Medicinal Chemistry, 2024: 116140.