COX-2/15-LOX/mPGES1-IN-1
COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments[1].
Product Specifications
UNSPSC
12352005
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-15-lox-mpges1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C/C1=COC2=C(C=CC(OC)=C2)C1=O)OCC3=CC=CC=C3
Molecular Formula
C19H16N2O5
Molecular Weight
352.34
References & Citations
[1]Elzahhar PA, et al. Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes. Eur J Med Chem. 2024 Jan 10;266:116138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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