RXR agonist 1
RXR agonist 1 (Compound 33) is a highly selective RXR agonist, with EC50s of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. RXR agonist 1 binds to RXR with high affinity (Kd = 0.03 μM) [1].
Product Specifications
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rxr-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
CC1(C)CCN(C2=CC(Cl)=NC(OCCC(O)=O)=N2)C3=C1C=CC=C3
Molecular Formula
C18H20ClN3O3
Molecular Weight
361.82
References & Citations
[1]Lewandowski M, et al. Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. J Med Chem. 2024 Jan 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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