RXR agonist 1
RXR agonist 1 (Compound 33) is a highly selective RXR agonist, with EC50s of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. RXR agonist 1 binds to RXR with high affinity (Kd = 0.03 μM) [1].
Product Specifications
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rxr-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
CC1(C)CCN(C2=CC(Cl)=NC(OCCC(O)=O)=N2)C3=C1C=CC=C3
Molecular Formula
C18H20ClN3O3
Molecular Weight
361.82
References & Citations
[1]Lewandowski M, et al. Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. J Med Chem. 2024 Jan 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
54661-01 10 mg
N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg
Sign In for Pricing
View Details 54661-02 25 mg
N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg
Sign In for Pricing
View Details 