MD102
MD102 is a potent TG2 inhibitor with an IC50 value of 0.35 μM. MD102 stabilizes p53 by inhibiting TG2, inducing a decrease in p-AKT and p-mTOR downstream signaling, leading to tumor cell apoptosis[1].
Product Specifications
CAS Number
[2755794-94-4]
UNSPSC
12352005
Target
Apoptosis; Glutaminase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/md102.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(C2=NC(C(C(Cl)=C(Cl)C3=O)=O)=C3N2)C=C1F
Molecular Formula
C13H4BrCl2FN2O2
Molecular Weight
389.99
References & Citations
[1]Kim GR, et al. Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma. Bioorg Chem. 2023 Dec 25;143:107061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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