MD102

MD102 is a potent TG2 inhibitor with an IC50 value of 0.35 μM. MD102 stabilizes p53 by inhibiting TG2, inducing a decrease in p-AKT and p-mTOR downstream signaling, leading to tumor cell apoptosis[1].

Product Specifications

CAS Number

[2755794-94-4]

UNSPSC

12352005

Target

Apoptosis; Glutaminase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/md102.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(C2=NC(C(C(Cl)=C(Cl)C3=O)=O)=C3N2)C=C1F

Molecular Formula

C13H4BrCl2FN2O2

Molecular Weight

389.99

References & Citations

[1]Kim GR, et al. Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma. Bioorg Chem. 2023 Dec 25;143:107061.