Trypanothione synthetase-IN-5
Product Specifications
UNSPSC Description
Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/trypanothione-synthetase-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]
Molecular Weight
728.61
References & Citations
[1]Exertier C, et al. Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J Med Chem. 2024 Jan 11;67(1):402-419.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162134/Trypanothione-synthetase-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162134/
Clinical Information
No Development Reported
Curated Selection
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