Trypanothione synthetase-IN-5

Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM[1].

Product Specifications

CAS Number

[3037664-05-1]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/trypanothione-synthetase-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]

Molecular Formula

C35H39F2IN4O3

Molecular Weight

728.61

References & Citations

[1]Exertier C, et al. Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J Med Chem. 2024 Jan 11;67 (1) :402-419.