HAChE/hBACE-1-IN-3

HAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier[1].

Product Specifications

UNSPSC

12352005

Target

Beta-secretase; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hache-hbace-1-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC4=C(N3)C=C(OC)C(OC)=C4

Molecular Formula

C25H31N3O3

Molecular Weight

421.53

References & Citations

[1]Banoo R, et al. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and β-secretase inhibitors. Eur J Med Chem. 2024 Jan 6;266:116131.