HAChE/hBACE-1-IN-3
HAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier[1].
Product Specifications
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-hbace-1-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC4=C(N3)C=C(OC)C(OC)=C4
Molecular Formula
C25H31N3O3
Molecular Weight
421.53
References & Citations
[1]Banoo R, et al. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and β-secretase inhibitors. Eur J Med Chem. 2024 Jan 6;266:116131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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