Tubulin polymerization-IN-58
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC50 of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research[1].
Target Antigen
Microtubule/Tubulin; YAP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-58.html
Solubility
10 mM in DMSO
Smiles
OC1=C(OC)C=CC(CN(C2=CC(OC)=C(OC)C(OC)=C2)C(CN3C=C(CSC4=NC5=C(C=CC=C5)S4)N=N3)=O)=C1
Molecular Weight
607.70
References & Citations
[1]Wu BW, et al. Design, synthesis and biological evaluation of 1,2,3-triazole benzothiazole derivatives as tubulin polymerization inhibitors with potent anti-esophageal cancer activities. Eur J Med Chem. 2024 Feb 5;265:116118.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162126/Tubulin-polymerization-IN-58-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162126/
Clinical Information
No Development Reported
Curated Selection
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