Tubulin polymerization-IN-58

Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC50 of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin; YAP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-58.html

Solubility

10 mM in DMSO

Smiles

OC1=C(OC)C=CC(CN(C2=CC(OC)=C(OC)C(OC)=C2)C(CN3C=C(CSC4=NC5=C(C=CC=C5)S4)N=N3)=O)=C1

Molecular Formula

C29H29N5O6S2

Molecular Weight

607.70

References & Citations

[1]Wu BW, et al. Design, synthesis and biological evaluation of 1,2,3-triazole benzothiazole derivatives as tubulin polymerization inhibitors with potent anti-esophageal cancer activities. Eur J Med Chem. 2024 Feb 5;265:116118.