PPARα/δ agonist 2

PPARα/δ agonist 2 (compound 14) is a potent PPARα and PPARδ agonist with EC50s of 3255 nM and 1475 nM for human PPARα and PPARβ/δ, respectively. PPARα/δ agonist 2 shows anti-inflammatory effects[1].

Product Specifications

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pparα-γ-agonist-4.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(COC2=CC(CCC(C)(CC/C=C(C)/CC/C=N/NC3=NC=C(Cl)C=C3C(F)(F)F)O4)=C4C=C2)C=C1

Molecular Formula

C31H32ClF4N3O2

Molecular Weight

590.05

References & Citations

[1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages. Eur J Med Chem. 2024 Jan 4;265:116125.