PRL-IN-1

PRL-IN-1 (compound 43) is a phosphatase of regenerating liver (PRL) inhibitor that directly binds the PRL1 trimer interface and obstructs PRL1 trimerization. PRL-IN-1 shows potent anticancer activities[1].

Product Specifications

CAS Number

[331431-75-5]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prl-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(N/N=C\C1=CC=C(C(O)=O)C=C1)C2=CC=CC(N3CC(C=C(C)C(C)=C4)=C4C3)=C2

Molecular Formula

C25H23N3O3

Molecular Weight

413.47

References & Citations

[1]Yunpeng Bai, et al. Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase. Cancer Res. 2016 Aug 15;76 (16) :4805-15.