TLR7 agonist 17
Product Specifications
UNSPSC Description
TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity[1].
Target Antigen
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-17.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N[C@H](CCO)CCC)=C(N(CC2=C(OC)C=C(CNC3CCOCC3)C=C2)N=C4)C4=N1
Molecular Weight
483.61
References & Citations
[1]Yam B. Poudel, et al. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology. CS Med. Chem. Lett. 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162115/TLR7-agonist-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162115/
Clinical Information
No Development Reported
CAS Number
2410517-32-5
Curated Selection
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