TLR7 agonist 17
TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity[1].
Product Specifications
CAS Number
2410517-32-5
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-17.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N[C@H](CCO)CCC)=C(N(CC2=C(OC)C=C(CNC3CCOCC3)C=C2)N=C4)C4=N1
Molecular Formula
C25H37N7O3
Molecular Weight
483.61
References & Citations
[1]Yam B. Poudel, et al. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology. CS Med. Chem. Lett. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7
Frequently Asked Questions
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