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TLR7 agonist 17

TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity[1].

Product Specifications

CAS Number

2410517-32-5

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-17.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(N[C@H](CCO)CCC)=C(N(CC2=C(OC)C=C(CNC3CCOCC3)C=C2)N=C4)C4=N1

Molecular Formula

C25H37N7O3

Molecular Weight

483.61

References & Citations

[1]Yam B. Poudel, et al. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology. CS Med. Chem. Lett. 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7

Frequently Asked Questions

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