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PARP1-IN-18

PARP1-IN-18 (compound 25) is a potent PARP1 inhibitor with an IC50 value of 2.7 nM. PARP1-IN-18 has anticancer effects[1].

Product Specifications

CAS Number

2958609-64-6

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp1-in-18.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1CC1)C2=CC=C(N3CCN(CC4=CC=C(C=C(C(F)F)C(N5)=O)C5=C4F)CC3)C(F)=N2

Molecular Formula

C24H23F4N5O2

Molecular Weight

489.47

References & Citations

[1]Sabnis RW. Novel Azaquinolones as PARP1 Inhibitors for Treating Cancer. ACS Med Chem Lett. 2021 Mar 16;12 (4) :524-525.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1

Frequently Asked Questions

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