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PROTAC GPX4 degrader-2

PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-gpx4-degrader-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CN(CCCCCCCC(N[C@@H]([C@H](O)C(N[C@@H](CC(C)C)C(OC)=O)=O)CC2=CC=CC=C2)=O)N=N1)C(C=C3)=CC=C3[C@H](N(C(CCl)=O)[C@@H](C(OC)=O)C4)C5=C4C6=CC=CC=C6N5

Molecular Formula

C50H61ClN8O9

Molecular Weight

953.52

References & Citations

[1]Haoze Song, et al. A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2023 Dec 31:265:116110.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GPX4

Curated Selection

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