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BRCA2-RAD51-IN-1

BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC50 value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity[1].

Product Specifications

CAS Number

[2830213-53-9]

UNSPSC

12352005

Target

RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brca2-rad51-in-1.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=CC(C(NC2=CC(C(F)(F)F)=NN23)=CC3=O)=C1

Molecular Formula

C13H7BrF3N3O

Molecular Weight

358.11

References & Citations

[1]Myers SH, et al. An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer. Eur J Med Chem. 2023 Dec 31;265:116114.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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