BRCA2-RAD51-IN-1
BRCA2-RAD51-IN-1 (Compound 46) is a BRCA2-RAD51 inhibitor with an EC50 value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
[2830213-53-9]
UNSPSC
12352005
Target
RAD51
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brca2-rad51-in-1.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=CC(C(NC2=CC(C(F)(F)F)=NN23)=CC3=O)=C1
Molecular Formula
C13H7BrF3N3O
Molecular Weight
358.11
References & Citations
[1]Myers SH, et al. An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer. Eur J Med Chem. 2023 Dec 31;265:116114.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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