Axl-IN-18
Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM) . Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model[1].
Product Specifications
CAS Number
3040329-68-5
UNSPSC
12352005
Target
Apoptosis; TAM Receptor
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
Molecular Formula
C32H26FN5O4
Molecular Weight
563.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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