MR-2088

MR-2088 is a selective ULK1/ULK2 inhibitor with pEC50 values of 8.3 and 8.7, respectively. MR-2088 selectively inhibits autophagy through ULK1/2 mediated inhibition[1].

Product Specifications

CAS Number

[2922531-69-7]

UNSPSC

12352005

Target

Autophagy; ULK

Type

Reference compound

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mr-2088.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC(F)(F)F)C1=CC(C2=CN=C3C(C=C(C4=CCCNC4)N3)=C2)=CS1

Molecular Formula

C19H17F3N4OS

Molecular Weight

406.42

References & Citations

[1]Alisa Morozova, et al. Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties. European Journal of Medicinal Chemistry. 29 December 2023, 116101.