PROTAC tubulin-Degrader-1
PROTAC tubulin-Degrader-1 is a α/β/β3-tubulin PROTAC degrader. PROTAC tubulin-Degrader-1 exhibits potent anti-proliferative activity against multiple human tumor cell lines. PROTAC tubulin-Degrader-1 induces G2/M phase arrest and apoptosis and inhibits colony formation in A549 and A549/Taxol cells. PROTAC tubulin-Degrader-1demonstrates potent anti-tumor efficacy in A549 and A549/Taxol (Taxol-resistant) xenograft model. PROTAC tubulin-Degrader-1 can be used for the study of non-small cell lung cancer (NSCLC) . (Pink: Tubulin ligand (HY-N2146), Blue: CRBN Ligand (HY-10984), Black: Linker (HY-N6056) ) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-tubulin-degrader-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C(OC)=CC(/C=C\C2=CC=C(OC)C(OC(CCCN3C(CCC(N4C(C(C(N)=CC=C5)=C5C4=O)=O)C3=O)=O)=O)=C2)=C1
Molecular Formula
C35H35N3O10
Molecular Weight
657.67
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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