RIPK1-IN-20
Product Specifications
UNSPSC Description
RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM)[1].
Target Antigen
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ripk1-in-20.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2=CC(C3=CN(CC4(COC4)C)C5=C3C(N)=NNC5=O)=CC=C21)CC6=CC(OC(F)(F)F)=CC=C6
Molecular Weight
553.53
References & Citations
[1]Chufeng Zhang, et al. Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors. Eur J Med Chem. 2023.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162097/RIPK1-IN-20-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162097/
Clinical Information
No Development Reported
CAS Number
3026543-19-8
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