RIPK1-IN-20

RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM) [1].

Product Specifications

CAS Number

[3026543-19-8]

UNSPSC

12352005

Target

Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ripk1-in-20.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC2=CC(C3=CN(CC4(COC4)C)C5=C3C(N)=NNC5=O)=CC=C21)CC6=CC(OC(F)(F)F)=CC=C6

Molecular Formula

C28H26F3N5O4

Molecular Weight

553.53

References & Citations

[1]Chufeng Zhang, et al. Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors. Eur J Med Chem. 2023.