BKN-1

BKN-1 is a bifunctional ligand that can not only track the formation of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) through far-red emission, but can also induce mitochondrial dysfunction. BKN-1 has anti-tumor activity and may cause mtDNA loss, damage mitochondrial integrity, reduce ATP levels, and trigger ROS imbalance, leading to apoptosis and autophagy[1].

Product Specifications

CAS Number

[1607831-82-2]

UNSPSC

12352005

Target

Apoptosis; Autophagy

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bkn-1.html

Solubility

10 mM in DMSO

Smiles

CCN1C2=C(C=C(/C=C/C3=[N+](C)C(C=CC4=C5C=CC=C4)=C5C3(C)C)C=C2)C6=C1C=CC=C6.[I-]

Molecular Formula

C31H29IN2

Molecular Weight

556.48

References & Citations

[1]Wang Z, et al. Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth. Eur J Med Chem. 2024 Jan 15;264:116046.