Antiproliferative agent-46
Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC50 value of 5.75 μM on the U87 cell line[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Casein Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-46.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(CC(C)C)C=C1)C(N/N=C/C2=CC=C(OCC(N/N=C/C3=CC=C(O)C=C3O)=O)C=C2)=O
Molecular Formula
C29H32N4O5
Molecular Weight
516.59
References & Citations
[1]Muhammad Ayaz, et al. Biooriented Synthesis of Ibuprofen-Clubbed Novel Bis-Schiff Base Derivatives as Potential Hits for Malignant Glioma: In Vitro Anticancer Activity and In Silico Approach. ACS Omega, 2023, 8, 51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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