T-1-MBHEPA
T-1-MBHEPA is a potent inhibitor of VEGFR-2, with the IC50 value of 0.121±0.051 μM. T-1-MBHEPA has anti-tumor and anti-angiogenic effect[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-1-mbhepa.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N(C)C=N1)=C1N2C)N(CC(NC3=CC=C(/C(C)=N/NC(C4=CC=CC(C)=C4)=O)C=C3)=O)C2=O
Molecular Formula
C25H25N7O4
Molecular Weight
487.51
References & Citations
[1]Ibrahim H Eissa, et al. Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2. Saudi Pharm J. 2023 Dec;31 (12) :101852.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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