HCAIX/XII-IN-9
HCAIX/XII-IN-9 (compound 8) is a potent carbonic anhydrase (CA) inhibitor with Ki values of 1658 nM, 184.8 nM, 8.9 nM, 64.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCC2=CC=C(S(=O)(N)=O)C=C2)C(SCC(N/N=C/C3=C(OC)C=CC=C3)=O)=NC4=CC=CC=C41
Molecular Formula
C26H25N5O5S2
Molecular Weight
551.64
References & Citations
[1]Adel S El-Azab, et al. Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. Saudi Pharm J. 2023 Dec;31 (12) :101866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII
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