EGFR WT/T790M/L858R-IN-1
EGFR WT/T790M/L858R-IN-1 (compound 10d) is a potent EGFR inhibitor, with IC50s of 0.097, 0.280, and 0.051 μM for EGFRWT, EGFRT790M, and EGFRL858R, respectively. EGFR WT/T790M/L858R-IN-1 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-wt-t790m-l858r-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(Cl)=C(C2C(C(CC(C)(C)C3)=O)=C3N(C4=CC=C(Cl)C=C4)C(N)=C2C(OCC)=O)C=C1
Molecular Formula
C26H25Cl3N2O3
Molecular Weight
519.85
References & Citations
[1]Al-Hamd MGA, et, al. Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R) . J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2241674.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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