Pim-1 kinase inhibitor 10
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation[1].
Product Specifications
CAS Number
2918764-57-3
UNSPSC
12352005
Target
Apoptosis; Caspase; Pim
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim-1-kinase-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(C2=CC3=C(NC2=O)C=CC=C3)C=C(C4=CC=CC(O)=C4)NC1=O
Molecular Formula
C21H13N3O3
Molecular Weight
355.35
References & Citations
[1]El-Miligy MMM, et, al. Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2152810.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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