8AQ−Cu−5Iu
8AQ Cu 5Iu is an activator of SIRT1. 8AQ Cu 5Iu exhibits neuroprotective effects by modulating the SIRT1/3-FOXO3a signaling pathway. 8AQ Cu 5Iu can used in study attenuating neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8aq-cu-5iu.html
Solubility
10 mM in DMSO
Smiles
IC(C(N1)=O)=C[N@@H]2C1=O[Cu]32[N]4=CC=CC5=C4C([NH2]3)=CC=C5
Molecular Formula
C13H11CuIN4O2
Molecular Weight
445.70
References & Citations
[1]Ruankham W, et al. Promising 8-Aminoquinoline-Based Metal Complexes in the Modulation of SIRT1/3-FOXO3a Axis against Oxidative Damage-Induced Preclinical Neurons. ACS Omega. 2023 Nov 30;8 (49) :46977-46988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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