AMPK activator 14
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes[1].
Product Specifications
CAS Number
1356632-18-2
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-activator-14.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C(C2CCN(CC2)C(C3=NC=C(C=C3)C(N[C@H]4CCN(CC5=CC=C(C=C5)C#N)C[C@@H]4F)=O)=O)=O
Molecular Formula
C33H34FN5O4
Molecular Weight
583.65
References & Citations
[1]Shaw SJ, et al. Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators. J Med Chem. 2023;66 (24) :17086-17104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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