AQIM-I

AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces ROS production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC50 value of 9 nM[1].

Product Specifications

CAS Number

2247881-73-6

UNSPSC

12352005

Target

Survivin

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aqim-i.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(C3=CC4=C(C=C31)C=CC=C4)=O)N(C=[N+]2C)C.[I-]

Molecular Formula

C17H13IN2O2

Molecular Weight

404.20

References & Citations

[1]Jing Yuan, et al. Pioneering 4,11-Dioxo-4,11-dihydro-1 H-anthra[2,3- d]imidazol-3-ium Compounds as Promising Survivin Inhibitors by Targeting ILF3/NF110 for Cancer Therapy. J Med Chem. 2023.