P-gp inhibitor 17

P-gp inhibitor 17 (compound 2g) is a P-gp inhibitor directly interacted with the transmembrane domain of P-gp. P-gp inhibitor 17 can be used for P-gp-mediated multidrug-resistant in tumor cells study[1].

Product Specifications

CAS Number

[2556388-58-8]

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-gp-inhibitor-17.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C4)(C5=NC(C6=CN=CC=C6)=NO5)C)C)=CC([C@]1([H])[C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC2)C)=O)C

Molecular Formula

C36H49N3O3

Molecular Weight

571.79

References & Citations

[1]Ziqian Wang, et al. Exploiting the “Hot-Spots” of Hsp70–Bim Protein–Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70–Bim Inhibitors. .Med. Chem. 2023, 66, 23, 16377–16387 Publication Date:November 27, 2023