P-gp inhibitor 17
Product Specifications
UNSPSC Description
P-gp inhibitor 17 (compound 2g) is a P-gp inhibitor directly interacted with the transmembrane domain of P-gp. P-gp inhibitor 17 can be used for P-gp-mediated multidrug-resistant in tumor cells study[1].
Target Antigen
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-17.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C4)(C5=NC(C6=CN=CC=C6)=NO5)C)C)=CC([C@]1([H])[C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC2)C)=O)C
Molecular Weight
571.79
References & Citations
[1]Ziqian Wang, et al. Exploiting the “Hot-Spots” of Hsp70–Bim Protein–Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70–Bim Inhibitors. .Med. Chem. 2023, 66, 23, 16377–16387
Publication Date:November 27, 2023
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162040/P-gp-inhibitor-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162040/
Clinical Information
No Development Reported
CAS Number
2556388-58-8
Curated Selection
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