PAT1inh-A0030
PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC50= 1.0 μM) . PAT1inh-A0030 inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption. PAT1inh-A0030 can be used in the study of intestinal diseases related to CF[1].
Product Specifications
CAS Number
1030097-65-4
UNSPSC
12352005
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pat1inh-a0030.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(N(CC2=CC=CC=C2)C)=C3C(ON=C3C)=N1)OCC
Molecular Formula
C17H18N4O3
Molecular Weight
326.35
References & Citations
[1]Chu T, et al. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC Med Chem. 2023 Sep 14;14 (11) :2342-2347.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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