MMT3-72
MMT3-72 is a weak inhibitor of JAK1. MMT3-72 has superior efficacy and reduced p-STAT3 in DSS-induced colitis[1].
Product Specifications
CAS Number
2996158-39-3
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mmt3-72.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCOC4=CC=C(/N=N/C5=CC=C(C(NCCC(O)=O)=O)C=C5)C=C4C(O)=O)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O
Molecular Formula
C40H42N8O9S
Molecular Weight
810.87
References & Citations
[1]Bu Y, et al. A gastrointestinal locally activating Janus kinase inhibitor to treat ulcerative colitis. J Biol Chem. 2023 Dec;299 (12) :105467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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