PB118
PB118 is a potent inhibitor of HDAC6 that plays an important role in the pathophysiology of Alzheimer's disease[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pb118.html
Solubility
10 mM in DMSO
Smiles
FC(C=C(C(NO)=O)C=C1)=C1CN2C3=CC=CC=C3CCCC2
Molecular Formula
C18H19FN2O2
Molecular Weight
314.35
References & Citations
[1]Prasenjit Mondal, et al. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology. Adv Sci (Weinh) . 2023 Nov 21:e2304545.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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