SB1617
SB1617 is a neuroinflammation-modulating agent, and has neuroprotective effect by reducing pathogenic tau levels through microglia-mediated anti-inflammatory activity[1][2].
Product Specifications
UNSPSC
12352005
Target
Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb1617.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(CN(C2=NN=CC3=C2[C@@H](OC4)N(S(C5=CC=C([N+]([O-])=O)C=C5)(=O)=O)[C@H]4CN3)C)C=C1
Molecular Formula
C22H21ClN6O5S
Molecular Weight
516.96
References & Citations
[1]Cho H, et al. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS Chem Neurosci. 2023;14 (23) :4139-4152.|[2]Shin YH, et al. Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling. Angew Chem Int Ed Engl. 2021;60 (4) :1831-1838. doi:10.1002/anie.202013915
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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