SB1617

SB1617 is a neuroinflammation-modulating agent, and has neuroprotective effect by reducing pathogenic tau levels through microglia-mediated anti-inflammatory activity[1][2].

Product Specifications

UNSPSC

12352005

Target

Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb1617.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(CN(C2=NN=CC3=C2[C@@H](OC4)N(S(C5=CC=C([N+]([O-])=O)C=C5)(=O)=O)[C@H]4CN3)C)C=C1

Molecular Formula

C22H21ClN6O5S

Molecular Weight

516.96

References & Citations

[1]Cho H, et al. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS Chem Neurosci. 2023;14 (23) :4139-4152.|[2]Shin YH, et al. Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling. Angew Chem Int Ed Engl. 2021;60 (4) :1831-1838. doi:10.1002/anie.202013915