S1g-10
S1g-10 is a Hsp70/Bim inhibitor, and shows antitumor activity in chronic myeloid leukemia cells[1].
Product Specifications
CAS Number
[3032432-71-3]
UNSPSC
12352005
Target
Bcl-2 Family; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s1g-10.html
Purity
99.08
Solubility
10 mM in DMSO
Smiles
O=C1C(C#N)=C(C2=CC=C(C3=C2C1=CC=C3)SC4CCCCC4)NCCN(CC)CC
Molecular Formula
C26H31N3OS
Molecular Weight
433.61
References & Citations
[1]Wang Z, et al. Exploiting the "Hot-Spots" of Hsp70-Bim Protein-Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70-Bim Inhibitors. J Med Chem. 2023;66 (23) :16377-16387.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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