NF-κB-IN-14
Product Specifications
UNSPSC Description
NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC50: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model[1].
Target Antigen
NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-14.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(/C=C/CN2C=NC3=C(Cl)N=C(Cl)N=C23)C=C1
Molecular Weight
319.19
References & Citations
[1]Pham L, et al. Synthesis of 9-Cinnamyl-9H-purine Derivatives as Novel TLR4/MyD88/NF-κB Pathway Inhibitors for Anti-inflammatory Effects. ACS Med Chem Lett. 2023 Nov 27;14(12):1839-1847.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162004/NF-κB-IN-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162004/
Clinical Information
No Development Reported
CAS Number
3019972-01-8
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