NF-κB-IN-14

NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC50: 6.4 μM) . NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model[1].

Product Specifications

CAS Number

[3019972-01-8]

UNSPSC

12352005

Target

NF-κB; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nf-κb-in-14.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(/C=C/CN2C=NC3=C(Cl)N=C(Cl)N=C23)C=C1

Molecular Formula

C15H12Cl2N4

Molecular Weight

319.19

References & Citations

[1]Pham L, et al. Synthesis of 9-Cinnamyl-9H-purine Derivatives as Novel TLR4/MyD88/NF-κB Pathway Inhibitors for Anti-inflammatory Effects. ACS Med Chem Lett. 2023 Nov 27;14 (12) :1839-1847.