Elliptinium (acetate)

Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2].

Product Specifications

CAS Number

[58337-35-2]

Product Name Alternative

NSC 264137; Celiptium

UNSPSC

12352005

Hazard Statement

H315-H319

Target

DNA Stain

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elliptinium-acetate.html

Solubility

10 mM in DMSO

Smiles

O=C(C)[O-].OC1=CC=C2NC3=C(C)C4=C(C=[N+](C)C=C4)C(C)=C3C2=C1

Molecular Formula

C20H20N2O3

Molecular Weight

336.38

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Dugue B, et al. Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture. Cancer Res. 1986 Aug;46 (8) :3828-33.|[2]Arteaga CL, et al. Elliptinium, a DNA intercalating agent with broad antitumor activity in a human tumor cloning system. Eur J Cancer Clin Oncol. 1987 Nov;23 (11) :1621-6.