CEP-11981 (tosylate)
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate) ) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1].
Product Specifications
CAS Number
901128-79-8
Product Name Alternative
ESK981 (tosylate) ; BOL 303213X (tosylate)
UNSPSC
12352005
Target
FGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/cep-11981-tosylate.html
Solubility
10 mM in DMSO
Smiles
O=S(O)(C1=CC=C(C)C=C1)=O.CC(C)CN(C2=C3C4=C(C(NC4)=O)C5=C2CCC6=NN(C)C=C65)C(C3=C7)=CC=C7NC8=NC=CC=N8
Molecular Formula
C35H35N7O4S
Molecular Weight
649.76
References & Citations
[1]Weiguo Jian, et al. The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma. Anticancer Res. 2014 Jul;34 (7) :3377-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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