Antitumor agent-136
Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a NAMPT inhibitor with an IC50 of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular NAMPT protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition[1].
Product Specifications
CAS Number
[2484876-94-8]
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-136.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C58H76N10O11S3
Molecular Weight
1185.48
References & Citations
[1], et al. NAMPT protein degradation targeting chimera and preparation method and application thereof. China. CN111454327. 2020-07028.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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