PROTAC KRAS G12D degrader 2
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro) . Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO) . The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker[1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/protac-kras-g12d-degrader-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/C(N1CCN(CC2CCN(C3=C(F)C=C(C(N(C(CCC(N4)=O)C4=O)C5=O)=O)C5=C3)CC2)CC1)=O)C[C@@H]6CCNC6=O)=O)OCC7=CC=CC=C7
Molecular Formula
C46H57FN8O9
Molecular Weight
884.99
References & Citations
[1]Grifagni D, et al. Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940757-100 1x 100 µL
Cytokeratin 7 (K72.7), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details